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Zou ZJ et al, 2017: Short-term efficacy and safety of low-intensity extracorporeal shock wave therapy in erectile dysfunction: a systematic review and meta-analysis.

Zou ZJ, Tang LY, Liu ZH, Liang JY, Zhang RC, Wang YJ, Tang YQ, Gao R, Lu YP.
Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.
Department of Urology, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, P.R. China.

Abstract

Aim: The role of low-intensity extracorporeal shock wave therapy (LI-ESWT) in erectile dysfunction (ED) is not clearly determined. The purpose of this study is to investigate the short-term efficacy and safety of LI-ESWT for ED patients.
Materials and Methods: Relevant studies were searched in Medline, Embase, CochraneLibrary, China National Knowledge Infrastructure (CNKI), WANFANG and VIP databases.Effective rate in terms of International Index of Erectile Function-Erectile FunctionDomain (IIEF-EF) and Erectile Hardness Score (EHS) at about 1month after LI-ESWTwas extracted from eligible studies for meta-analysis to calculate risk ratio (RR) ofeffective treatment in ED patients treated by LI-ESWT compared to those receivingsham-treatment.
Results: Overall fifteen studies were included in the review, of which four randomized controlled trials (RCTs) were for meta-analysis. Effective treatment was 8.31 [95% confidenceinterval (CI): 3.88-17.78] times more effective in the LI-ESWT group (n=176)than in the sham-treatment group (n=101) at about 1 month after the intervention interms of EHS, while it was 2.50 (95% CI: 0.74-8.45) times more in the treatment group(n=121) than in the control group (n=89) in terms of IIEF-EF. Nine-week protocol withenergy density of 0.09mJ/mm2 and 1500 pluses seemed to have better therapeutic effectthan five-week protocol. No significant adverse event was reported.
Conclusion: LI-ESWT, as a noninvasive treatment, has potential short-term therapeutic effect on patients with organic ED irrespective of sensitivity to PDE5is. Owing to the limited number and quality of the studies, more large-scale, well-designed and longterm follow-up time studies are needed to confirm our analysis.

IBJU 2017; 43 March 1.[Ahead of print] doi: 10.1590/S1677-5538.IBJU.2016.0245

 

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Commenti 1

Hans-Göran Tiselius il Mercoledì, 28 Febbraio 2018 09:46

Low-intensity ESWT for erectile dysfunction is currently intensively discussed in the literature. This article is a review (n=15) and meta-analysis (n=4) of literature data. Although the results show a positive short-term effect the authors find it necessary with larger and well controlled studies for more definite conclusions.

Low-intensity ESWT for erectile dysfunction is currently intensively discussed in the literature. This article is a review (n=15) and meta-analysis (n=4) of literature data. Although the results show a positive short-term effect the authors find it necessary with larger and well controlled studies for more definite conclusions.
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